HomeNewsNew DNA Chip Can Perform Complex Math Calculations

Related Articles

New DNA Chip Can Perform Complex Math Calculations

A new chip automates reaction cascades between molecules inside DNA to perform complex mathematical calculations.

The word ‘DNA’ immediately brings to mind the double-stranded helix that contains all of our genetic information. But the separate units of its two parts are pairs of molecules that are selectively attached to each other. As it turns out, this pair of properties can be leveraged to perform complex mathematical calculations, and is the basis of DNA computing.

Since DNA consists of only two strands, performing a simple calculation requires several simple chemical reactions using different sets of DNA. In most current research, DNA is manually inserted into a reaction tube for each reaction, which makes the process very cumbersome. Microfluidic chips, which have narrow channels engraved on a plastic-like material, offer a way to automate the process. But despite their promises, the use of microfluidic chips for DNA computing has not been explored.

In a recent article – made available online on ACS Nano on July 7, 2021, and published in July 27, 2021, issue 15, issue 7 – a team of scientists from Incheon National University (INU) in Korea has described a program presented. A DNA-based microfluid is doing the chip that can be controlled by a personal computer to perform DNA calculations. “Our hope is that DNA-based CPUs will replace electronic CPUs in the future because they use less power, which will help combat global warming. DNA-based CPUs are also a platform for mathematical modeling, such as deep learning solutions and complex arithmetic. INU’s Dr. Young Joon Song, who led the research, says.

Dr. Song and his team used 3D printing to build their microfluidic chip, which can perform Boolean logic, one of the core logics of computer programming. Boolean logic is a type of true or false logic that compares inputs and returns a value of ‘true’ or ‘false’ depending on the type of operation or ‘logic gate’. The door to logic in this experiment consists of a trapped DNA template. The isolated single stranded DNA was then used as input. If any part of the input DNA is a Watson Crack sequence complementary to the template DNA, it is fused to form double-stranded DNA. Depending on the size of the final DNA, the product was declared true or false.

What makes the designed chip unusual is the motorized valve system that can be operated via a PC or smartphone. The chip and software setup together make up the microfluidic processing unit (MPU). Thanks to the valve system, the MPU can provide multiple answers to quickly and easily perform a combination of logic operations.

This unique valve system from MPU based on programmable DNA paves the way for more complex cascades that can code for extended functions. “Future research will focus on total DNA computing solutions with DNA algorithms and DNA storage systems,” says Dr.

With such a solid proof of concept, it’s not hard to imagine that a DNA-based computer has become an everyday thing!

Latest Posts

error: Content is protected !!